Pyridostigmine in postpolio syndrome: no decline in fatigue and limited functional improvement

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Pyridostigmine in postpolio syndrome: no decline in fatigue and limited functional improvement.

OBJECTIVES To investigate the effect of pyridostigmine on fatigue, physical performance, and muscle function in subjects with postpoliomyelitis syndrome. METHODS 67 subjects with increased fatigue and new weakness in one quadriceps muscle showing neuromuscular transmission defects, were included in a randomised, double blind, placebo controlled trial of 60 mg pyridostigmine four times a day f...

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Circadian variation of fatigue in paralytic poliomyelitis and postpolio syndrome: just fatigue or masked restless legs syndrome?

Dear Editors We read with interest the manuscript published by Viana et al.. These authors observed in a small cohort of paralytic poliomyelitis (PP) and postpolio syndrome (PPS) patients a significant circadian fatigue in both forms. The authors also evaluated polysomnographic variables lacking correlations between PSG data and fatigue. In PP, an acute disease resulting in flaccid paralysis, i...

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Postpolio syndrome.

Keywords Disease name and synonyms Diagnostic criteria/Definition Differential diagnosis Prevalence Risk indicators Clinical description Management including treatment Etiology Diagnostic methods Unresolved questions References Abstract Post-poliomyelitis syndrome or post-polio syndrome (PPS) is the commonly accepted term to describe the neuromuscular symptoms that may develop many years after ...

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Poliomyelitis and the postpolio syndrome.

In developed countries as well as in Hungary polio virus related disease disappeared completely due to the extensive administering of vaccine. As a result, young and middle-aged doctors have no experience of encountering acute polio virus infection but instead they meet its resultant impairments and disabilities. Persons who had suffered the onset of poliomyelitis 3 or 4 decades earlier, may to...

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Postpolio syndrome and anesthesia.

The development of polio vaccines 50 yr ago essentially halted childhood polio epidemics in the industrialized world. During the past quarter century, a constellation of delayed neuromuscular symptoms, called postpolio syndrome, became recognized among the aging polio survivors. The prevalence of postpolio syndrome in the U.S. population is estimated to be in the hundreds of thousands. The most...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 2003

ISSN: 0022-3050

DOI: 10.1136/jnnp.74.12.1655